Leaky gut Syndrom
The normally tight intestinal cellular wall junctions keep undigested food particles and pathogenic microbes from entering the blood stream while allowing nutrients to enter that same bloodstream. The opening of those intercellular tight junctions (increased intestinal permeability) can allow passage of fragments of food, microbes, microbial products, and foreign antigens to get past the intestinal epithelium and into the bloodstream and rest of the body. This can result in activation of the immune system or an Immune respons and secretion of inflammatory mediators.
The opening of intercellular tight junctions (increased intestinal permeability) allows uncontrolled passage of substances, like food fragments, into the bloodstream, with subsequent possible development of immune and/or inflammatory reactions.
The breaking of the intestinal barrier and the passage into the general circulation of these substances are the common starting point for multiple pathologies.
First of all bowel disorders, that is to say, diarrhea or loose stools, bloating and abdominal pain. Then the passage of these exogenous molecules in the blood and in the lymph will cause a blood poisoning, then a Liver overload (persistent general fatigue), a chronic inflammatory process, an immune response that may overload the person's immunesystem and leading to immune system disorders. The intestinal mucosa lining is extremely important for the immune system - and accounts for up to 80% of the immune system itself.
Immune disorders is a factor in many diseases, such as Crohn's disease, celiac disease, Sjogren's syndrome, ulcerative colitis, type 1 diabetes, type 2 diabetes, sclerosis plaque, rheumatoid arthritis, spondyloarthropathies, inflammatory bowel disease,irritable bowel syndrome, schizophrenia, fungal infections, certain types of cancer,] obesity, fatty liver, and allergic diseases in all their forms (asthma, eczema, rhinitis) or to food intolerances (intolerance to gluten, milk, casein ...) , among others. In the many cases, increased permeability develops prior to disease, but the cause–effect relationship between increased intestinal permeability in most of these diseases is not clear.
Bacterial pathogens, (such as cholera), fungals (Mycelial with roots), select enteric viruses, and parasites modulate intestinal tight junction structure and function, and these effects may contribute to the development of chronic intestinal disorders. Stress and infections also seem to cause perturbations in intestinal permeability. Disruption of the intestinal tight junction barrier can act as a trigger for many different diseases.